Naringin Reduces Hyperglycemia-Induced Cardiac Fibrosis by Relieving Oxidative Stress
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Naringin Reduces Hyperglycemia-Induced Cardiac Fibrosis by Relieving Oxidative Stress
INTRODUCTION Hyperglycemia promotes myocardial fibrotic lesions through upregulation of PKC and p38 in response to redox changes. The effects of naringin on hyperglycemia-induced myocardial fibrotic changes and its putative effects on PKC-β and p38 protein expression in type 1 rat model of diabetes are hereby investigated. METHODS Male Sprague-Dawley rats were divided into six groups I-VI. Gr...
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ژورنال
عنوان ژورنال: PLOS ONE
سال: 2016
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0149890